The best Side of ceesdekker
The best Side of ceesdekker
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Utilizing solitary-molecule optical and AFM imaging and force-spectroscopy techniques, we request to unravel the mechanistic components of the structure and dynamics of chromosomes. Our investigate passions contain:
It absolutely was only inside the nineteen nineties however, when nanotechnology experienced Superior to the degree wherever single molecules may very well be manipulated, that the very first experimental products began to seem.
Back in 1991, Sumio Iijima from the NEC Corporation had noted the synthesis of carbon nanotubes. Band framework calculations prompt that these nanotubes could show metallic band conduction. This is able to be a substantial gain over the conducting polymers we had explored, which were, in reality, disordered semiconductors supplying simply variable-assortment hopping conductivity.
Due to the fact 2000, Dekker has shifted the primary emphasis of his work in direction of biophysics where he reports the Attributes of single biomolecules and cells using the instruments of nanotechnology. This transformation of subject was pushed by his fascination for the amazing working of biological molecular buildings, in addition to with the lengthy-phrase perspective that lots of appealing discoveries may be anticipated In this particular industry.[five] Present lines of study in his biophysics group are from the parts of:[six]
This yielded a breakthrough. Within just only a few months, we ended up capable of evaluate transport as a result of a person one-walled carbon nanotube. Depending on small-temperature experiments by a brilliant PhD university student in my group, Sander Tans (now a valued colleague and professor at Delft College of Technologies by having an active investigation lab at AMOLF in Amsterdam), we showed that carbon nanotubes have been legitimate quantum wires with really extensive (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.
Our investigate ranges within the biophysics of DNA to artificial cells and outside of. You should take a look beneath with the spectrum of our current projects.
A lot of linked developments adopted, wherever our team recognized unique transistor variants which include one-electron transistors at place temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled numerous transistors into smaller proof-of-principle electronic circuits.
Case in point (1) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in gray, the rim of the pore is highlighted in purple, and a 3D rendering with the movement from the DNA rod is exhibited.
What if, instead of working with standard major-down silicon electronics, transistors could possibly be built from The underside up using solitary organic molecules as being the switching elements? This concept, ceesdekker.net which turned The idea of now’s discipline of molecular electronics, to start with emerged inside the nineteen seventies.
Resolving the step dimension in condensin-pushed DNA loop extrusion identifies ATP binding because the stage-producing course of action
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division
Afterwards we spoke once again briefly for the reason that Dekker felt that our dialogue of his faith rapidly grew to become purely philosophical, whereas Furthermore, it concretely can help him in his work.
Developments in nanotechnology inside the 1990s created creating electronic gadgets from single molecules a chance. Cees Dekker recounts how his group developed a space-temperature transistor depending on an individual carbon nanotube.
2004, discovery of new physics in translocation of DNA by nanopores; very first experimental study of ions conduction in nanofluidic channels; to start with electrochemistry with specific single-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; initial electrical docking of microtubules on kinesin-coated nanostructures; to start with biophysics characterization on the mechanical Qualities of double-stranded RNA; and to start with single-molecule analyze of DNA translocation by a restriction-modification enzyme.